Liver Transplantation Criteria For Hepatocellular Carcinoma Should Be Expanded: A 22-Year Experience With 467 Patients at UCLA

摘要

We analyzed the outcomes of 467 patients who underwent orthotopic liver transplantation for hepatocellular carcinoma over a 22-year period at our center. Patients with tumors meeting the Milan and University of California, San Francisco, criteria had >50% overall and recurrence-free survival rates at 5 years, whereas patients with tumors beyond University of California, San Francisco criteria fared much worse. On multivariate analysis, tumor number, lymphovascular invasion, and poor differentiation were independent predictors of survival.